Pneumonia Innovations Network Newsletter


CPAP innovations and pneumonia webinar

Our next Pneumonia Innovations Network webinar event will be held on Thursday, January 18, 2018 at 10AM EST. The webinar topic will be CPAP innovations and pneumonia. Join us for presentations by Mohammod Chisti: Non-invasive ventilation in managing childhood pneumonia: Bangladesh scenario
Eric McCollum: CPAP IMPACT (Improving Mortality for Pneumonia in African Children Trial) in Malawi
Patrick Wilson: Effectiveness of Continuous Positive Airway Pressure (CPAP) in Children with Undifferentiated Respiratory Distress in a Lower-Middle-Income Country

Webinar access details will be sent via email after the New Year. We hope you join us!

Mark your calendars

January 18, 2018
Pneumonia Innovations Network webinar event: CPAP innovations and pneumonia

A Comment from the Coordinator

We are currently working on developing a webpage for the PIN. We hope to have the website up and running early in 2018. Keep your eyes open for details soon to come!

Pneumonia Innovations Network Member and Partner Updates

Lifebox, oximetry innovation and pediatric pneumonia:

Pneumonia Innovations Network member Lifebox has been redesigning their highly regarded pulse oximeter, an instrument originally designed for safe surgery, so that it can be used to help detect pneumonia in small children. The new probe was presented at this year's WSPID Congress.

Find out more from Dr. Eric McCollum, pediatric pulmonologist at Johns Hopkins & one of the senior members of the #LifeboxPneumoniaInnovation team:

Articles and news

Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication corhort study by Michael Moore, Beth Stuart, Paul Little, Sue Smith, Matthew J. Thompson, Kyle Knox, Anne van den Bruel, Mark Lown, David Mant

Published in the European Respiratory Journal 2017, Moore et. al. share the primary findings in their investigation of clinical features predictive of radiograph-confirmed pneumonia diagnoses in patients presenting with lower respiratory tract symptoms in routine primary care.

"The confirmation of pneumonia by radiography within 7;days of consultation is uncommon in adults presenting in primary care with LRTI 115 out of 28883 (0.4%). The significant independent predictors of pneumonia in those receiving a chest radiograph within 1;week of consultation were temperature >37.8°C, crackles on auscultation, oxygen saturation <95% and pulse >100·min–1. Most patients with pneumonia (99/115, 86.1%) exhibited at least one of these four clinical signs. The positive predictive value of having at least one sign was 20.2% (95% I17.3–23.1)."

Read the full article at:

Clinical signs accurately identify pneumonia, study suggests, a comment by Jennifer Garcia and published November 29, 2017 is also available.

"Four clinical variables may help in identifying patients with pneumonia in primary care settings ... The authors note that previous studies have found fever, crackles, and elevated pulse rate to be predictors for the presence of pneumonia. However, unlike the current best diagnostic model, the presence of a runny nose was not found to be significant in the present study. In contrast, the addition of pulse oximetry has demonstrated clinical utility in previous retrospective studies in the primary care setting."

Read the full comment here:

Appropriateness of clinical severity classification of new WHO childhood pneumonia guidance: a multi-hospital, retrospective, cohort study by Ambrose Agweyu, PhD, Richard J Lilford, PhD, and Mike English, MD

A multi-hospital, retrospective cohort study by Ambrose Agweyu et. al. assesses whether some children categorized as eligible for outpatient treatment have a risk of death warranting their treatment in hospital."In settings of high mortality, WAZ less than 3 SD or any degree of pallor among children with non-severe pneumonia was associated with a clinically important risk of death. Our data suggest that admission to hospital should not be denied to children with these signs and we urge clinicians to consider these risk factors in addition to WHO criteria in their decision making." Read the full article at:

Also see Kim Mulholland's follow-up commentary, Problems with the WHO guidelines for management of childhood pneumonia, which identifies the urgent need for the review and revision of the current WHO/IMCI pneumonia case management strategy:" Of the children who died, at least 322 (39%) would have been classified by WHO as having non-severe pneumonia requiring home treatment by the 2013 revision. These children actually did die despite inpatient treatment, but the fact that the WHO IMCI revision would have sent them home raises very serious questions ... The study by Agweyu and colleagues gives some indication of the potentially serious consequences of this policy change." Read the commentary at:

Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis, The Lancet Infectious Diseases, January 2018

Earlier this year, the use of procalcitonin in guiding antibiotic therapy for patients with acute respiratory infections was approved by the US Food and Drug Administration. To assess the safety of procalcitonin-guided treatments with ARI in different clinical settings, Prof. Philipp Schuetz, et al. conducted a meta-analysis of 26 randomized controlled trials. "Widespread implementation of procalcitonin protocols in patients with acute respiratory infections thus has the potential to improve antibiotic management with positive effects on clinical outcomes and on the current threat of increasing antibiotic multiresistance."

Read the full article here:

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Saturday, 18 January 2020