Respiratory Viruses Frequently Mimic Pertussis in Young Infants

by Damouni Shalabi, Ranaa, MD; Srugo, Isaac, MD; Golan-Shany, Orit, PhD; Kugelman, Amir, MD; Bamberger, Ellen, MD

To be published in The Pediatric Infectious Disease Journal, May 2019.

 

Bordetella pertussis is prevalent among infants, but its diagnosis is complicated by the fact that its signs and symptoms overlap with respiratory viruses. Indeed, when evaluating the etiology of infants less than 1 year of age suspected of having pertussis, resesarchers found that respiratory viruses frequently mimic B. pertussis and are more likely to be the causative agent.

 

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High-density Bacterial Nasal Carriage in Children Is Transient and Associated With Respiratory Viral Infections—Implications for Transmission Dynamics

by Thors, Valtyr, MD, PhD; Christensen, Hannah, PhD; Morales-Aza, Begonia, BSc; Oliver, Elizabeth, BSc; Sikora, Paulina, BSc; Vipond, Ian, PhD; Muir, Peter, MD, PhD; Finn, Adam, MD, PhD

To be published in The Pediatric Infectious Disease Journal, May 2019.

 

 

This longitudinal study describes the associations between respiratory viral infections, rhinitis and the prevalence and density of the common nasopharyngeal bacterial colonizers, Streptococcus pneumoniae (Sp), Moraxella catarrhalis (Mc), Haemophilus influenzae (Hi) and Staphylococcus aureus.

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Predictors of Poor Outcomes Among Infants With Respiratory Syncytial Virus–associated Acute Lower Respiratory Infection in Botswana

by Patel, Sweta M., MD; Spees, Lisa, PhD; Smieja, Marek, MD; Luinstra, Kathy, BSc; Steenhoff, Andrew P., MBBCh; Feemster, Kristen A., MD; Arscott-Mills, Tonya, MD; Boiditswe, Sefelani, BNSc; Patel, Mohamed Z., MBBCh; Shah, Samir S., MD; Cunningham, Coleen K., MD; Kelly, Matthew S., MD

To be published in The Pediatric Infectious Disease Journal, May 2019. 

 

 

Among children 1–23 months of age with respiratory syncytial virus–associated acute lower respiratory infection in Botswana, young age (<6 months), household use of wood as a cooking fuel, moderate or severe malnutrition and oxygen saturation <90% on room air were independent predictors of clinical nonresponse at 48 hours. Among HIV-uninfected infants less than six months of age, HIV exposure was associated with a higher risk of in-hospital mortality.

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Influenza-associated Hospitalization in Children Younger Than 5 Years of Age in Suzhou, China, 2011–2016

by Yu, Jia, MPH; Zhang, Xiyan, MPH; Shan, Wei, MPH; Gao, Junmei, MPH; Hua, Jun, MD; Tian, Jianmei, MD; Ding, Yunfang, MD; Zhang, Jun, MD; Chen, Liling, MD; Song, Ying, MD; Zhou, Suizan, MPH; Iuliano, A. Danielle, PhD; Greene, Carolyn M., MD; Zhang, Tao, PhD; Zhao, Genming, PhD

To be published in The Pediatric Infectious Disease Journal, May 2019.

 

 

Studying the burden and risk factors associated with severe illness from influenza infection in young children in eastern China will contribute to future cost-effectiveness analyses of local influenza vaccine programs.

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Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection

by Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Jessica Thomas, Sara Mertz, Daniel M Cohen, Octavio Ramilo, and Asuncion Mejias

Published in The Journal of Infectious Diseases, 12 November 2018. 

 

 

The association between respiratory syncytial virus (RSV) loads and clinical outcomes in children remains to be defined. In most studies, viral loads (VL) were evaluated in hospitalized children and at a single time-point. Researchers investigated the relationship between VLs and disease severity in both outpatients and inpatients with RSV infection.

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