Burden of Streptococcus pneumoniae sepsis in children after introduction of pneumococcal conjugate vaccines - a prospective population-based cohort study

by Sandra A Asner, MD, MSc; Philipp K A Agyeman, MD; Eugénie Gradoux, MD; Klara M Posfay-Barbe, MD, MSc; Ulrich Heininger, MD; Eric Giannoni, MD; Pierre A Crisinel, MD; Martin Stocker, MD; Sara Bernhard-Stirnemann, MD, MSc; Anita Niederer-Loher, MD; Christian R Kahlert, MD; Paul Hasters, MD; Christa Relly, MD; Walter Baer, MD; Christoph Aebi, MD; Luregn J Schlapbach, MD; Christoph Berger, MD; Swiss Paediatric Sepsis Study group

Published in Clinical Infectious Diseases, 02 January 2019. https://doi.org/10.1093/cid/ciy1139

 

 

Population-based studies assessing the impact of pneumococcal conjugate vaccines (PCV) on burden of pneumococcal sepsis in children are lacking. Researchers aimed to assess this burden following introduction of PCV-13 in a nationwide cohort study.

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Impact of the 23-valent pneumococcal polysaccharide vaccination in pregnancy against infant acute lower respiratory infections in the Northern Territory of Australia

by Binks MJ, Moberley SA, Balloch A, Leach AJ, Nelson S, Hare KM, Wilson C, Nelson J, Morris PS, Ware RS, Tang MLK, Torzillo PJ, Carapetis JR, Mulholland K, and Andrews RM

Published in Pneumonia, 25 December 2018.

 

 

Indigenous children in Australia's Northern Territory are densely colonised with the pneumococcus within weeks of birth antecedent to a high prevalence of acute lower respiratory infection (ALRI). Researchers assessed the impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in pregnancy against infant ALRI in this setting.

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Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

by Olga Bengård Hansen, MD; Amabelia Rodrigues, PhD; Cesario Martins, PhD; Andreas Rieckmann, PhD; Christine Stabell Benn, DMSc; Peter Aaby, DMSc; and Ane Bærent Fisker, PhD

Published in the Journal of Tropical Pediatrics, 24 December 2018. https://doi.org/10.1093/tropej/fmy075

 

In addition to vaccines’ specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6–59 months in Guinea-Bissau.

 

Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, researchers compared all-cause consultation rates after vs. before the campaign, stratified by participation status.

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Impact and cost effectiveness of pneumococcal conjugate vaccine in India

by Yuvaraj Krishnamoorthy, Salin K.Eliyas, Nayana P.Nair, Manikandanesan Sakthivel, Gokul Sarveswaran, and Palanivel Chinnakali

Published in Elsevier: Vaccine, 23 December 2018. https://doi.org/10.1016/j.vaccine.2018.12.004

 

 

World Health Organization has recommended the introduction of pneumococcal conjugate vaccine (PCV) in the childhood immunisation programme of all the countries in the world. In lieu of its introduction in India, there is a need to generate evidence on cost-effectiveness of this vaccine. This study looks into the impact and cost-effectiveness of PCV vaccine in India.

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Interventions to help people understand community immunity: A systematic review

by Hina Hakim, Thierry Provencher, Christine T. Chambers, S. Michelle Driedger, Eve Dube, Teresa Gavaruzzi, Anik M. C. Giguere, Noah M. Ivers, Shannon MacDonald, Jean-Sebastien Paquette, Kumanan Wilson, Daniel Reinharz, and Holly O. Witteman

Published in Vaccine, 07 January 2019. https://doi.org/10.1016/j.vaccine.2018.11.016

 

 

Herd immunity, or community immunity, occurs when susceptible people in a population are indirectly protected from infection thanks to the pervasiveness of immunity within the population. In this study, researchers aimed to systematically review interventions designed to communicate what community immunity is and how community immunity works to members of the general public.

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