by van de Garde MDB, van Westen E, Poelen MCM, Rots NY, van Els CACM
Published in Infection and Immunity, 25 March 2019.
CD4+ T-cell mechanisms are implied in protection against pneumococcal colonization; however, their target antigens and function are not well defined. In contrast to high-throughput protein arrays for serology, basic antigen tools for CD4+ T-cell studies are lacking. Here researchers evaluate the potential of a bioinformatics tool in silico prediction of immunogenicity as a method to reveal domains of pneumococcal proteins targeted by human CD4+ T-cells.