Integrated Safety Profile of a New Approved, Fully Liquid DTaP5-HB-IPV-Hib Vaccine

by Jin Xu, PhD; Jon E. Stek, MS; Eddy Ziani, MD; G. Frank Liu, PhD; Andrew W. Lee, MD

Published in The Pediatric Infectious Disease Journal, April 2019. doi: 10.1097/INF.0000000000002257

 

 

DTaP5-HB-IPV-Hib is a fully liquid, hexavalent vaccine containing a 5-antigen pertussis component, approved since 2016 in Europe [Vaxelis; DTaP5-HB-IPV-Hib vaccine: Diphtheria, tetanus, pertussis (5 acellular components: pertussis toxoid [PT], filamentous haemagglutinin [FHA], pertactin (PRN), and fimbriae Types 2 and 3 [FIM]), hepatitis B (recombinant DNA: rDNA), poliomyelitis (inactivated) and Haemophilus influenzae type b conjugate vaccine (adsorbed); MCM Vaccine B.V., The Netherlands] for primary and booster vaccination in infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b. The comparator vaccine (control) was INFANRIX hexa (GlaxoSmithKline Biologics S.A., Rixensart, Belgium) (DTaP3-IPV-HepB/Hib) in European studies and PENTACEL (DTaP5-IPV/Hib) (Sanofi Pasteur, Swiftwater, PA) in US studies.

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Invasive Pneumococcal Disease in Neonates Prior to Pneumococcal Conjugate Vaccine Use in South Africa 2003–2008

by Krishnee Moodley, MBChB, FCPath, MMed; Yacoob Mahomed Coovadia, MBChB, FCPathSA; Cheryl Cohen, MBChB, PhD; Susan Meiring, MBChB, DTM&H; Sarona Lengana, MBChB, DipHIVManSA; Linda De Gouveia, NDMed Tech; Claire von Mollendorf, MBChB, MSc, PhD; Penny Crowther-Gibson, MSc, MSc; Vanessa Quan, MBChB, MPH; Brian Eley, MBChB; Gary Reubenson, MBBCh, FCPaed; Trusha Nana, MBChB, FCPath, MMed; Anne von Gottberg, MBChB, PhD

Published in The Pediatric Infectious Disease Journal, April 2019. doi: 10.1097/INF.0000000000002096

 

 

Neonatal invasive pneumococcal disease (IPD) in developing countries is poorly described. Researchers provide a baseline description of neonatal IPD in South Africa, before implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in 2009.

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The True Cost of Measles Outbreaks During the Postelimination Era

by Maria E. Sundaram, MSPH, PHD; L. Beryl Guterman, MSPH; Saad B. Omer, MBBS, MPH, PhD

Published in JAMA, 07 March 2019. doi: 10.1001/jama.2019.1506

 

 

"A large measles outbreak in Washington State has prompted officials to declare a state of emergency. As of March 4, 2019, the Washington State Health Department reported 71 confirmed cases, with the majority of cases among individuals who were not vaccinated or who had an unverified vaccination status. The outbreak is centered in a geographic cluster of persistently high vaccine exemption rates among young children. This cluster has persisted despite the overall reduction in vaccine exemptions in the state of Washington, subsequent to the introduction of legally mandated health care practitioner counseling of parents seeking vaccine exemptions.

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Influenza Epidemiology, Vaccine Coverage and Vaccine Effectiveness in Children Admitted to Sentinel Australian Hospitals in 2017: Results from the PAEDS-FluCAN Collaboration

by Christopher C Blyth, Kristine K Macartney, Jocelynne McRae, Julia E Clark, Helen S Marshall, Jim Buttery, Joshua R Francis, Tom Kotsimbos, Paul M Kelly, and Allen C Cheng

Published in Clinical Infectious Diseases, 05 March 2019. https://doi.org/10.1093/cid/ciy597

 

 

In 2017, Australia experienced record influenza notifications. Two surveillance programs combined to summarize the epidemiology of hospitalized influenza in children and report on vaccine effectiveness (VE) in the context of a limited nationally funded vaccination program.

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Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin

by Chuchalin AG, Onishchenko GG, Kolosov VP, Kurganova OP, Zaitseva TA, Manakov LG, Kholodok GN, Perelman JM, Kozlov RS, Ivakhnishina NM, Trotsenko OE, Bondarenko AP

Published in Interdisciplinary perspectives on infectious diseases, 18 February 2019. 

 

 

Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society. The flood in the Amur river basin in the summer of 2013 created a special zone and risk conditions for the formation of respiratory pathology in the Far-Eastern region of Russia. Researchers aimed to give clinical and epidemiological assessment of the effectiveness of vaccination programs of respiratory viral and pneumococcal infections and generalization of regional experience in the organization of a set of measures aimed at their prevention in the postflood period in the Far-Eastern region.

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