Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Invasive Disease Caused by Serotype 3 in Children: A Systematic Review and Meta-analysis of Observational Studies

By Heather L Sings, Philippe De Wals, Bradford D Gessner, Raul Isturiz, Craig Laferriere, John M McLaughlin, Stephen Pelton, Heinz-Josef Schmitt, Jose A Suaya, Luis Jodar

Clinical Infectious Diseases, to be published June 15, 2019

 

The 13-valent pneumococcal conjugate vaccine (PCV13) is the only licensed PCV with serotype 3 polysaccharide in its formulation. Postlicensure PCV13 effectiveness studies against serotype 3 invasive pneumococcal disease (IPD) in children have shown inconsistent results.  We performed a systematic review and meta-analysis of observational studies to assess PCV13 vaccine effectiveness (VE) for serotype 3 IPD in children. We systematically searched PubMed, Embase, and the Cochrane library for studies published before 14 August 2017. We identified 4 published studies and 2 conference posters that provided PCV13 VE estimates stratified by serotype. The pooled PCV13 VE against serotype 3 IPD from the random-effects meta-analysis was 63.5% (95% confidence interval [CI], 37.3%–89.7%). A sensitivity analysis including conference posters gave a pooled VE estimate of 72.4% (95% CI, 56.7%–88.0%). The pooled data from case-control studies with similar methodologies and high quality support direct PCV13 protection against serotype 3 IPD in children.

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Determinants of Influenza and Pertussis Vaccination Uptake in Pregnancy

By Christopher R. Wilcox, Anna Calvert, Jane Metz, Eliz Kilich, Rachael MacLeod, Kristen Beadon, Paul T. Heath, Asma Khalil, Adam Finn, Matthew D. Snape, Tushna Vandrevala, Tom Nadarzynski, Matthew A. Coleman, Christine E. Jones

The Pediatric Infectious Disease Journal, June 2019

 

Uptake rates of antenatal vaccination remain suboptimal. Our aims were to determine (1) the acceptability of routine vaccination among pregnant women, (2) the confidence of maternity healthcare professionals (HCPs) discussing vaccination and (3) HCP opinion regarding the optimum healthcare site for vaccine administration.

Separate questionnaires for pregnant women and HCPs were distributed within 4 national health service (NHS) trusts in South England (July 2017 to January 2018).

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Low-cost pneumonia vaccine breaks into global market

By Ann Danaiya Usher

The Lancet, May 18, 2019  

Keith Klugman, the director of the Bill and Melinda Gates Foundation's Pneumonia programme, also welcomed the new, cheaper product. “We are excited by this because there are other vaccines that Gavi is interested in and has approved. Hopefully, this will free up Gavi funds for vaccines that, so far, have not rolled out in developing countries, like typhoid and cholera vaccine.” Another vaccine in the late stages of development that Gavi might be able to fund is against respiratory syncytial virus, a leading viral cause of pneumonia deaths among children in developing countries during the first 6 months of life, he says

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Intraseason Waning of Influenza Vaccine Effectiveness

By G Thomas Ray, Ned Lewis, Nicola P Klein, Matthew F Daley, Shirley V Wang, Martin Kulldorff, Bruce Fireman

Clinical Infectious Diseases, May 15, 2019

In the United States, it is recommended that healthcare providers offer influenza vaccination by October, if possible. However, if the vaccine’s effectiveness soon begins to wane, the optimal time for vaccination may be somewhat later. We examined whether the effectiveness of influenza vaccine wanes during the influenza season with increasing time since vaccination.

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Influenza Vaccine Effectiveness and Statin Use Among Adults in the United States, 2011–2017

By Fiona P Havers, Jessie R Chung, Edward A Belongia, Huong Q McLean, Manjusha Gaglani, Kempapura Murthy, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson

Clinical Infectious Diseases, May 15, 2019

 

Statin medications have immunomodulatory effects. Several recent studies suggest that statins may reduce influenza vaccine response and reduce influenza vaccine effectiveness (VE)

 

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