Influenza Vaccine Effectiveness in Preventing Influenza-associated Hospitalizations During Pregnancy: A Multi-country Retrospective Test Negative Design Study, 2010–2016

By Mark G Thompson, Jeffrey C Kwong, Annette K Regan, Mark A Katz, Steven J Drews, Eduardo Azziz-Baumgartner, Nicola P Klein, Hannah Chung, Paul V Effler, Becca S Feldman, Kimberley Simmonds, Brandy E Wyant, Fatimah S Dawood,  Michael L Jackson, Deshayne B Fell, Avram Levy, Noam Barda, Lawrence W Svenson, Rebecca V Fink, Sarah W Ball, Allison Naleway

Clinical Infectious Diseases, May 2019


The Pregnancy Influenza Vaccine Effectiveness Network (PREVENT) consisted of public health or healthcare systems with integrated laboratory, medical, and vaccination records in Australia, Canada (Alberta and Ontario), Israel, and the United States (California, Oregon, and Washington). Sites identified pregnant women aged 18 through 50 years whose pregnancies overlapped with local influenza seasons from 2010 through 2016. Administrative data were used to identify hospitalizations with acute respiratory or febrile illness (ARFI) and clinician-ordered real-time reverse transcription polymerase chain reaction (rRT-PCR) testing for influenza viruses. Overall IVE was estimated using the test-negative design and adjusting for site, season, season timing, and high-risk medical conditions


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Also read the associated editorial “Influenza Vaccination During Pregnancy Can Protect Women Against Hospitalization Across Continents” by Flor M Munoz


 “Pregnant women and young infants are among the most vulnerable victims of influenza epidemics and pandemics. The documented higher risk of influenza morbidity and mortality in pregnant women and infants is compounded by the paucity of data on effective interventions to prevent and treat influenza infection in these populations who have traditionally been excluded from research. The impact of influenza in pregnancy has been recognized for decades through observations made during the twentieth-century pandemics and during seasonal interpandemic periods, and recommendations to vaccinate pregnant...”


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Wednesday, 26 February 2020