By Christopher J Stewart, Jonathan M Mansbach, Nadim J Ajami, Joseph F Petrosino, Zhaozhong Zhu, Liming Liang, Carlos A Camargo, Jr, Kohei Hasegawa
The Journal of Infectious Diseases, June 15, 2019.
Emerging evidence suggests relationships between the nasopharyngeal metabolome and both the microbiota and severity of bronchiolitis. However, the influence of host systemic metabolism on disease pathobiology remains unclear. We aimed to examine metabolome profiles and their association with more-severe disease, defined by use of positive pressure ventilation (PPV), in infants hospitalized for bronchiolitis.