Disproportionate Exposure to Antibiotics in Children at Risk for Invasive Pneumococcal Disease: Potential for Emerging Resistance and Opportunity for Antibiotic Stewardship

by Barlam TF, Morgan JR, Kaplan WA, Outterson K, Pelton SI.

Published in J Pediatric Infect Dis Soc. 2017 Sep 07. PMID: 28992176.


Researchers compared antibiotic prescribing for children with and those without an underlying chronic condition associated with increased risk for invasive pneumococcal disease. Children with a chronic condition had significantly greater cumulative exposure to antibiotics and higher rates of prescriptions per person-year than those without a chronic condition; this population is at increased risk for the emergence of multidrug-resistant pathogens.


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Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews

Disparate interventions to change antibiotic prescribing behaviour for acute respiratory infections (ARIs) have been trialled and meta-analysed, but not yet synthesised in an overview. This overview synthesises evidence from systematic reviews, rather than individual trials.


"This systematic review analysis provides moderate-quality evidence that three types of strategies probably help to reduce antibiotic prescribing in primary care. Shared decision making between doctors and their patients, C-reactive protein tests, and procalcitonin-guided management likely reduce antibiotic prescribing in general practice."Read the full article here. 

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